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KMID : 0363620180390040126
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Journal of Korean Oriental Medicine
2018 Volume.39 No. 4 p.126 ~ p.135
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Effects of GHX02 on Chronic Obstructive Pulmonary Disease Mouse Model
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Yang Won-Kyung
Lyu Yee-Ran
Kim Seung-Hyung
Park Yang-Chun
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Abstract
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Objectives: Chronic obstructive pulmonary disease (COPD) is characterized by chronic inflammation and irreversible airflow. This study aimed to evaluate the effects of GHX02 in a COPD-induced mouse model.
Methods: The COPD mouse model was established by exposure to cigarette smoke extract and lipopolysaccharide which were administered by intratracheal injection three times with a 7 day interval. GHX02 (100, 200, 400 mg/kg) and all other drugs were orally administrated for 14 days from Day 7 to Day 21.
Results: GHX02 significantly decreased the neutrophil counts in bronchoalveolar lavage fluid (BALF) and the number of CD4+, CD8+, CD69+, and CD11b+/GR1+ cells in BALF and lung cells. GHX02 also suppressed the secretion of tumor necrosis factor-alpha (TNF-α), interleukin-17A, macrophage inflammatory protein 2 (MIP2), and chemokine (C?X?C motif) ligand 1 (CXCL-1) in BALF and ameliorated the lung pathological changes.
Conclusions: Thus, GHX02 effectively inhibited airway inflammation by inhibiting migration of inflammatory cells and expression of pro-inflammatory cytokines. Therefore, GHX02 may be a promising therapeutic agent for COPD.
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KEYWORD
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chronic obstructive pulmonary disease, cigarette smoke, airway inflammation, herbal medicine, GHX02
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